Botulinum Neurotoxin and Tetanus Toxin by Lance Simpson

By Lance Simpson

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of motion, pathogenesis, and therapy of clostridial neurotoxins. The booklet is prepared into 4 elements encompassing 18 chapters that debate the starting place, constitution, pharmacology, toxicology, immunology, assays, and scientific problems with botulinum and tetanus neurotoxins.
The introductory a part of the e-book discusses the invention and construction of neurotoxins in quite a few lines of Clostridium micro organism. this article additionally describes how particular bacteriophages and plasmids mediate the pathogenicity of a few forms of Clostridium botulinum and Clostridium tetani. the following half presents an summary of matters regarding toxin binding, together with pollution which may function types for botulinum and tetanus neurotoxins. Discussions at the peripheral and valuable features of poisoning delivery within the primary anxious process and at the hostile medicinal drugs for clostridial neurotoxins are supplied. The 3rd a part of the booklet addresses the antibodies opposed to botulinum neurotoxin. Bioassay in mice and hugely delicate immunoassays, equivalent to reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are awarded. The concluding half covers the animal versions for those pollution and discusses the prognosis and therapy of botulism and tetanus in human. The scientific use of Clostridium botulinum toxin kind A in ocular and neuromuscular affliction can be tested.
This booklet may be of price to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

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